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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T71744	Imazodan	PDE	Metabolism
	Imazodan 是一种具有正性肌力活性的小分子化合物，是选择性III型磷酸二酯酶抑制剂，可用于研究心力衰竭。
T1265	Amrinone Inamrinone,Inocor,氨力农,Wincoram	TNF; PDE	Apoptosis; Metabolism
	Amrinone (Inocor) 是一种正性肌力血管扩张剂，是一种具有口服活性的，非糖苷和非儿茶酚胺的强心剂，也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂，能够防止环磷酸腺苷分解，从而增加环磷酸腺苷水平。
T32997	LY 249933 LY249933,LY-249933
	LY 249933 is a cardioselective 1, 4-dihydropyridine with positive inotropic activity.
T68742	Inamrinone lactate
	Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
T68600	Enoximone sulfoxide
	Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.
T69107	Doxaminol
	Doxaminol is a synthetic partial beta-adrenergic agonist with sympathomimetic activity. Doxaminol may bind to and stimulate beta-1-adrenergic receptors located in the myocardium. As a result, it leads to a positive inotropic effect and increases in cardiac output.
T5033L	Olprinone Hydrochloride
	Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 由于具有正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。

化合物

Vesnarinone

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Synonym: Inamrinone,Inocor,氨力农,Wincoram

Target: TNF, PDE

LY 249933

Cat.No: T32997

Synonym: LY249933,LY-249933

Olprinone Hydrochloride

Cat.No: T5033L

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T4S0823	Astragaloside	Others	Others
	Astragaloside 能够保护大鼠海马形态结构，恢复乙酰胆碱水平，并能够使脑电图正常化改善脑功能。